modified teleform, version 7.0 Search Results


hepes ph7 0  (Jena Bioscience)
92
Jena Bioscience hepes ph7 0
Hepes Ph7 0, supplied by Jena Bioscience, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/pmc05394238-231-37-11?v=Jena+Bioscience
Average 92 stars, based on 1 article reviews
hepes ph7 0 - by Bioz Stars, 2026-07
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1m tris-hcl, ph 7.0. , sterile  (Teknova)
90
Teknova 1m tris-hcl, ph 7.0. , sterile
1m Tris Hcl, Ph 7.0. , Sterile, supplied by Teknova, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/custom%40t1070%4028654248?v=Teknova
Average 90 stars, based on 1 article reviews
1m tris-hcl, ph 7.0. , sterile - by Bioz Stars, 2026-07
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3-piece foldable iol externity x-70  (Santen SAS)
90
Santen SAS 3-piece foldable iol externity x-70
3 Piece Foldable Iol Externity X 70, supplied by Santen SAS, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/pmc05903096-24-14-16?v=Santen+SAS
Average 90 stars, based on 1 article reviews
3-piece foldable iol externity x-70 - by Bioz Stars, 2026-07
90/100 stars
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pharmascan 70/16 system  (BioSpec)
90
BioSpec pharmascan 70/16 system
Pharmascan 70/16 System, supplied by BioSpec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/pmc12274961-88-8-11?v=BioSpec
Average 90 stars, based on 1 article reviews
pharmascan 70/16 system - by Bioz Stars, 2026-07
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mri biospec 70/20usr  (BioSpec)
90
BioSpec mri biospec 70/20usr
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
Mri Biospec 70/20usr, supplied by BioSpec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/pmc05920064-286-11-13?v=BioSpec
Average 90 stars, based on 1 article reviews
mri biospec 70/20usr - by Bioz Stars, 2026-07
90/100 stars
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7.0 t biospec 70/30 horizontal animal scanner  (BioSpec)
90
BioSpec 7.0 t biospec 70/30 horizontal animal scanner
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
7.0 T Biospec 70/30 Horizontal Animal Scanner, supplied by BioSpec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/pmc09906381-260-10-11?v=BioSpec
Average 90 stars, based on 1 article reviews
7.0 t biospec 70/30 horizontal animal scanner - by Bioz Stars, 2026-07
90/100 stars
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7.0 t scanner  (BioSpec)
90
BioSpec 7.0 t scanner
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
7.0 T Scanner, supplied by BioSpec, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/pmc09184653-278-6-9?v=BioSpec
Average 90 stars, based on 1 article reviews
7.0 t scanner - by Bioz Stars, 2026-07
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usr, bruker  (Bruker Corporation)
98
Bruker Corporation usr, bruker
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
Usr, Bruker, supplied by Bruker Corporation, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/pmc04464978-132-12-13?v=Bruker+Corporation
Average 98 stars, based on 1 article reviews
usr, bruker - by Bioz Stars, 2026-07
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v 70  (STATA Corporation)
99
STATA Corporation v 70
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
V 70, supplied by STATA Corporation, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/10__1590_slash_1678___4162___9739-65-1-17?v=STATA+Corporation
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v 70 - by Bioz Stars, 2026-07
99/100 stars
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r-101 from dupont  (DuPont de Nemours)
90
DuPont de Nemours r-101 from dupont
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
R 101 From Dupont, supplied by DuPont de Nemours, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/modified+teleform%2C+version+7%2E0/us08394879-333-56-58?v=DuPont+de+Nemours
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r-101 from dupont - by Bioz Stars, 2026-07
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1m sodium phosphate buffer, ph 7.0. , sterile  (Teknova)
90
Teknova 1m sodium phosphate buffer, ph 7.0. , sterile
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
1m Sodium Phosphate Buffer, Ph 7.0. , Sterile, supplied by Teknova, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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1m sodium phosphate buffer, ph 7.0. , sterile - by Bioz Stars, 2026-07
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pluriol ® e300  (BASF)
90
BASF pluriol ® e300
In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c <t>MRI</t> images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast <t>agent</t> <t>Fe-MGD</t> ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented
Pluriol ® E300, supplied by BASF, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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pluriol ® e300 - by Bioz Stars, 2026-07
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Image Search Results


In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c MRI images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast agent Fe-MGD ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented

Journal: Nature Communications

Article Title: Optically-controlled bacterial metabolite for cancer therapy

doi: 10.1038/s41467-018-03233-9

Figure Lengend Snippet: In vivo NO generation and anti-cancer effect of PMT system. a Schematic illustration of the NO responsive element contained sensing plasmid and its in vitro NO responsiveness ( n = 3). b In vivo NO generation of PMT system in 4T1 Nrf2-luc tumor-bearing mice. The imaging was performed 24 h after the i.v. injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), and CCN (5 mg mL −1 in 200 μL saline). c MRI images for detecting both in vitro and in vivo NO generation with the assistance of NO responsive contrast agent Fe-MGD ( n = 3). The in vivo imaging was performed 24 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). d Imaging apoptotic response in vivo with annexin V-Cy5.5 (Red: CCN@ E. coli , Green: apoptotic cancer cells). The in vivo imaging was performed 48 h after the i.v. injection of CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline). e Semiquantitative analysis of relationship among intratumoral NO concentration (evaluated by the circle area), bacteria count, and signal intensity of apoptotic cells ( n = 3). f Schematic diagram of the process of in vivo anti-cancer therapy. Intravenous injection of E. coli , CCN@ E. coli (10 8 CFU mL −1 in 200 μL saline), CCN (5 mg mL −1 in 200 μL saline) and phosphate buffer solution treated group (PBS) were performed on the 1st and 7th days ( n = 6). Light irradiation was performed 24 h after the injection ( > 630 nm, 30 mW cm −2 , 15 min). g In vivo anti-cancer effect of PMT in 4T1 tumor-bearing mice ( n = 6). h In vivo anti-cancer effect of PMT in CT26 tumor-bearing mice ( n = 6). i H&E staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). j TUNEL staining of 4T1 tumor after 14 days of PMT (Scale bar: 100 μm). k Three-dimensional fluorescence imaging for visualizing the co-localization of CCN@ E. coli and apoptotic region within the tumor. Significance between every two groups was calculated using unpaired two-tailed Student’s t -test. * P < 0.05, ** P < 0.01, *** P < 0.001. The mean values and S.D. are presented

Article Snippet: The relaxivity of (MGD) 2 -Fe(II)-NO was measured on a 7.0 T MRI (BioSpec 70/20USR).

Techniques: In Vivo, Plasmid Preparation, In Vitro, Imaging, Injection, Saline, In Vivo Imaging, Concentration Assay, Bacteria, Irradiation, Staining, TUNEL Assay, Fluorescence, Two Tailed Test